Table. 1.

Table. 1.

International Neuroblastoma Pathology Classification [7,13]

Favorable histology Unfavorable histology
Neuroblastoma (Schwannian stroma-poor)
Undifferentiated subtype All Tumors (Any MKI, Any Age)
Poorly differentiated subtype Low or Intermediate MKI, <548 days Low or Intermediate MKI, ≥548 days
High MKI, Any Age
Differentiating subtype Low MKI, <5 years Any MKI, ≥5 years
Intermediate MKI, ≥548 days
High MKI, Any Age
Ganglioneuroblastoma, intermixed (Schwannian stroma-rich) All Tumors
Ganglioneuroma (Schwannian stroma-dominant)
Maturing subtype All Tumors
Mature subtype All Tumors
Ganglioneuroblastoma, Nodular (composite, Schwannian stroma-rich/ Stroma-dominant and stroma-poor) Favorable histology vs. unfavorable histology distinction: based on age-linked evaluation of Grade of neuroblastic differentiation (subtype) and MKI of the neuro-blastoma nodule

MKI, Mitosis Karyorrhexis Index; Low, (<100/5,000 cells); Intermediate, (100-200/5,000 cells); High, (>200/5,000 cells)

Clin Pediatr Hematol Oncol 2020;27:73-86
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