Table. 3.

Table. 3.

Laboratory tests for measurement of iron status [3]

Iron deficiency Iron deficiency anemia IRIDA Anemia of chronic disease Iron-deficiency anemia and anemia of chronic disease
Conventional test (normal range)
Iron (10-30 mmol/L) Low Low Low Low Low
Transferrin saturation (16-45%) ≥16 <16 <10 Low-normal Low-normal
Hemoglobin Normal Low Low Low Low
Men (>13 g/dL)
Women (>12 g/dL)a)
Ferritin <30 <10-15 Variable >100 <100
Men (40-300 mg/L)
Women (20-200 mg/L)
Mean corpuscular volume (80-95 fL) Normal Low Very low Low-normal Low-normal
New-investigation test
sTFR (mg/L)b) High High High High High
sTFR/log ferritin indexb) NA >2 NA <1 >2
Hepcidin (ng/mL)b) Usually ≤10 Very low Normal-high High Normal-high
Zinc protoporphyrin (mmol/mol heme)b) Normal High High High High
Reticulocyte hemoglobin content (31.2±1.6 pg) <25 Low Low Low Low
Perl’s staining of bone marrow Negative Negative Positive Strongly positive Positive

IRIDA, iron-refractory iron deficiency anemia; sTFR, Soluble transferrin receptor

a)If, pregnant women >11 g/dL. b)Normal values vary according to the method of measurement used

Clin Pediatr Hematol Oncol 2020;27:101-12
© 2020 Clin Pediatr Hematol Oncol