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Original Article
Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
Clin Pediatr Hematol Oncol 2016;23:77-82.
Published online October 31, 2016
© 2016 Korean Society of Pediatric Hematology-Oncology

Keun Young Kim, M.D.1, Young Min An, M.D.1, Tae Wan Kim, M.D.1, Yong Hun Jun, M.D., Ph.D.1, Ji Eun Lee, M.D., Ph.D.1, Jun Hyuk Jang, Ph.D.2 and Soon Ki Kim, M.D., Ph.D.1

Departments of 1Pediatrics, 2Biological Chemistry, Inha University School of Medicine, Incheon, Korea
Correspondence to: Soon Ki Kim
Department of Pediatrics, Inha University School of Medicine, 7-206, Sinhung-dong 3ga, Jung-gu Incheon 22332, Korea Tel: +82-32-890-3518Fax: +82-32-890-2844E-mail: ID:
Received September 20, 2016; Revised October 4, 2016; Accepted October 15, 2016.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Iron pots have long been used for cooking in several countries. Early studies have shown that the use of such iron pots can increase the iron content of food cooked in them and that this increased iron content has some effect on iron uptake. This study was designed to evaluate the iron content in rice cooked in a traditional iron pot and study the iron uptake by macrophages through heme oxygenase-1 (HO-1). Methods: The iron pot used in this study was round-shaped and had no legs. The iron content of rice cooked in the iron pot was measured. Thereafter, the bioavailability of iron was measured using western blot analysis.Results: A total of 35 samples were analyzed for iron concentrations, which were 10.94± 18.08 mg/L (range: 0.18-56.53 mg/L). The biochemical activity in most of materials was 1.5-9 times that of the activity observed in the control group.Conclusion: The iron concentration of rice cooked in iron pots were found to be relatively high. The introduction of iron pots in routine cooking practices may be a promising way of increasing the supply of iron, especially for people with severe iron deficiency anemia. Further, increased activity of HO-1, induced by supplementation of iron from the cast iron, may help in maintaining iron homeostasis.
Keywords: Iron pots, Iron, Iron deficiency anemia, Heme oxygenase-1
  1. Carter RC, Jacobson JL, Burden MJ, et al. Iron deficiency anemia and cognitive function in infancy. Pediatrics 2010;126: e427-34.
    Pubmed KoreaMed CrossRef
  2. Congdon EL, Westerlund A, Algarin CR, et al. Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. J Pediatr 2012;160:1027-33.
    Pubmed KoreaMed CrossRef
  3. Charles CV, Dewey CE, Daniell WE, Summerlee AJ. Iron-deficiency anaemia in rural Cambodia: community trial of a novel iron supplementation technique. Eur J Public Health 2011;21: 43-8.
    Pubmed CrossRef
  4. Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 2002;27:8-16.
    Pubmed CrossRef
  5. Choi BM, Pae HO, Jeong YR, et al. Overexpression of heme oxygenase (HO)-1 renders Jurkat T cells resistant to fas-mediated apoptosis: involvement of iron released by HO-1. Free Radic Biol Med 2004;36:858-71.
    Pubmed CrossRef
  6. Kröger-Ohlsen MV, Trúgvason T, Skibsted LH, Michaelsen KF. Release of iron into foods cooked in an iron pot: effect of ph, salt, and organic acids. J Food Sci 2002;67:3301-3.
  7. Borigato EV, Martinez FE. Iron nutritional status is improved in Brazilian preterm infants fed food cooked in iron pots. J Nutr 1998;128:855-9.
  8. Kulkarni SA, Ekbote VH, Sonawane A, Jeyakumar A, Chiplonkar SA, Khadilkar AV. Beneficial effect of iron pot cooking on iron status. Indian J Pediatr 2013;80:985-9.
    Pubmed CrossRef
  9. Beck KL, Conlon CA, Kruger R, Coad J. Dietary determinants of and possible solutions to iron deficiency for young women living in industrialized countries: a review. Nutrients 2014;6: 3747-76.
    Pubmed KoreaMed CrossRef
  10. Sharieff W, Dofonsou J, Zlotkin S. Is cooking food in iron pots an appropriate solution for the control of anaemia in developing countries? A randomised clinical trial in Benin. Public Health Nutr 2008;11:971-7.
    Pubmed CrossRef
  11. Andrews NC. Forging a field: the golden age of iron biology. Blood 2008;112:219-30.
    Pubmed KoreaMed CrossRef
  12. Chang TP, Rangan C. Iron poisoning: a literature-based review of epidemiology, diagnosis, and management. Pediatr Emerg Care 2011;27:978-85.
    Pubmed CrossRef

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  • Soon Ki Kim