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Original Article
Clinical Course of Childhood Immune Thrombocytopenic Purpura and Analysis Predicting Factor of Prognosis
Clin Pediatr Hematol Oncol 2017;24:88-92.
Published online October 31, 2017
© 2017 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Taekwan Lee, M.D., Jinhyuk Choi, M.D. and Yeon-Jung Lim, M.D., Ph.D.

Department of Pediatrics, Chungnam National University College of Medicine, Daejeon, Korea
Correspondence to: Yeon-Jung Lim
Department of Pediatrics, Chungnam National University Hospital, 282 Munwha-ro, Jung-gu, Daejeon 35015, Korea
Tel: +82-42-280-7247 Fax: +82-42-255-3158 E-mail: pedonco@cnuh.co.kr
Received September 25, 2017; Revised October 8, 2017; Accepted October 12, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Immune thrombocytopenic purpura (ITP) is an acquired bleeding disorder in which the immune system destroys platelets. There were many studies which predicted the factors associated with the prognosis of childhood ITP, but controversies remained. We analyzed the predicting factors associated with the clinical outcome and prognosis of pediatric patients with newly diagnosed ITP in a single institution.Methods: We reviewed retrospectively the medical records of 170 patients with newly diagnosed ITP at Chungnam National University Hospital (CNUH) from January 2005 to December 2015. The demographics, complete blood count (CBC), leukocyte differ-ential counts and treatment of patients with ITP were reviewed.Results: The median age at diagnosis were 20 months old (range, 0 to 189 months) for acute ITP and 52 months old for chronic ITP. After initial diagnosis of ITP, 20 of 170 patients (11.8%) were later diagnosed as chronic ITP. Age at diagnosis and absolute lymphocyte count (ALC) at diagnosis were statistically correlated with development of chronic ITP. ALC at diagnosis and at discharge were significantly higher in acute ITP patients than chronic ITP patients. We determined that ALC >4,109/μL at diagnosis and ALC >3,825/μL at discharge were associated with platelet recovery after 12 months. Conclusion: This study demonstrated that that high ALC at admission and discharge predict a favorable outcome in children with newly diagnosed ITP. Further studies are warranted to validate these findings.
Keywords: Children, Immune thrombocytopenia, Prognostic factor, Absolute lympho-cyte count
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October 2018, 25 (2)
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  • Yeon-Jung Lim