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Case Report
A Case of Recurrent Steroid-dependent Kikuchi–Fujimoto Disease Successfully Treated with Hydroxychloroquine
Clin Pediatr Hematol Oncol 2017;24:144-7.
Published online October 31, 2017
© 2017 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Kyung Mi Jang, M.D. and Jae Min Lee, M.D.

Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea
Correspondence to: Jae Min Lee
Department of Pediatrics, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
Tel: +82-53-620-3536 Fax: +82-53-629-2252 E-mail:
Received August 24, 2017; Revised September 11, 2017; Accepted October 9, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Kikuchi–Fujimoto disease (KFD) is known as a self-limiting disease. The most common symptoms include fever, cervical lymphadenopathy, and pain, but nonspecific symptoms such as joint pain, nausea, chills, diaphoresis, and diarrhea may also be present. Its clinical course is generally benign, and symptoms including fever disappear within several months without special treatment. Thus, there is no specific recommended treatment for patients with KFD. However, some patients suffer from prolonged fever or systemic symptoms such as splenomegaly, skin rash, arthralgia, and aseptic meningitis. Many studies have reported the effectiveness of corticosteroids in patients with prolonged fever and systemic symptoms. Our patient also responded favorably to steroids; however, the disease relapsed while tapering. Recently, some studies reported the effectiveness of hydroxychloroquine (HC) in patients with KFD. Herein, we report successful treatment with HC in an adolescent patient with recurrent KFD dependent on steroids without any symptoms of autoimmune disease.
Keywords: Kikuchi–Fujimoto disease, Histiocytic necrotizing lymphadenitis, Hydroxy-chloroquine, Children, Lymphadenopathy
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October 2018, 25 (2)
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  • Jae Min Lee