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Case Report
A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13)
Clin Pediatr Hematol Oncol 2017;24:148-52.
Published online October 31, 2017
© 2017 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Hye-ji Kim, M.D.1, Hyery Kim, M.D.1, Kyung-Nam Koh, M.D.1, Ho Joon Im, M.D.1, Jong Jin Seo, M.D.1, Eul-Ju Seo, M.D.2 and Chan-Jeoung Park, M.D.3

1Department of Pediatrics, 2Genetic Medical Center, 3Department of Laboratory Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Correspondence to: Jong Jin Seo
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-3383 Fax: +82-2-473-3725 E-mail: jjseo@amc.seoul.kr
Received September 19, 2017; Revised September 24, 2017; Accepted September 25, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities of the leukemic blast. Concurrent MYC and IGH/BCL2 translocations have recently been reported as a “double hit” in adult patients, but non-immunoglobulin (non-IG)/MYC translocation has rarely been reported. In this paper, we report a case of pediatric precursor B-cell ALL associated with translocations (14;18)(q32;q21) and (8;9)(q24;p13). The patient was a previously healthy 13-year-old boy. Complete remission was not achieved after first-line four-drug induction chemotherapy; thus, intensive salvage regimen, including high-dose cytarabine and L-asparaginase, were administered, which resulted in morphologic remission. However, his dis-ease relapsed during the second cycle of salvage regimen, and he died of sepsis-induced multiorgan failure.
Keywords: Pediatric, Precursor B-cell lymphoblastic leukemia, Translocations, MYC, BCL2
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April 2018, 25 (1)
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  • Jong Jin Seo