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Review Article
Basic Understanding of Iron Metabolism
Clin Pediatr Hematol Oncol 2018;25:1-9.
Published online April 30, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Jin Kyung Suh, M.D., Ph.D., In-sang Jeon, M.D.

Department of Pediatrics, College of Medicine, Gachon University, Incheon, Korea
Correspondence to: In-sang Jeon
Department of Pediatrics, College of Medicine, Gachon University, 21 Namdongdaero 774 beongil, Namdong-gu, Incheon 21565,Korea
Tel: +82-32-460-8382 Fax: +82-32-460-3224
E-mail: isjeon@gilhospital.com
Received March 26, 2018; Revised April 3, 2018; Accepted April 9, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Iron is critical for almost all living organisms because it serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism. Disruption of iron homeostasis is associated with a wide range of diseases. Thus mammals have developed sophisticated mechanisms to maintain optimal range of iron concentration. Iron regulation involves processes at the systemic and cellular levels. These processes are regulated by hepcidin and iron regulatory proteins. Hepcidin modulates systemic iron homeostasis with ability to impede cellular iron export via interaction with the iron export protein, ferroportin. Whereas, iron regulatory proteins control cellular iron homeostasis by translational regulation of proteins which involve iron metabolism. Recent advances in the study of iron metabolism have shown promising results that hepcidin-targeted strategies may help to improve the diagnosis and treatment of iron related diseases. Although these strategies are now under development, ongoing studies can help to elucidate its application possibilities.
Keywords: Iron metabolism, Iron metabolism disorders, Hepcidin
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October 2018, 25 (2)
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  • In-sang Jeon