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Original Article
Family History as a Risk Factor for Iron Deficiency Anemia among Korean Adolescents: Data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES)
Clin Pediatr Hematol Oncol 2018;25:31-7.
Published online April 30, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Hee Won Chueh, M.D., Ph.D.1, Yun Chang Choi, M.D.1, Jung Hyun Shin, M.D.2, Jae Ho Yoo, M.D., Ph.D.1

1Department of Pediatrics, College of Medicine, Dong-A University, 2Department of Pediatrics, Good Gangan Hospital, Busan, Korea
Correspondence to: Jae Ho Yoo
Department of Pediatrics, College of Medicine, Dong-A University Hospital, 26 Daesingongwon-ro, Seo-gu, Busan 49201, Korea
Tel: +82-51-240-2648 Fax: +82-51-242-2765 E-mail: pedendo@dau.ac.kr
Received March 25, 2018; Revised April 5, 2018; Accepted April 9, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Iron deficiency anemia (IDA) is a disease prevalent throughout the world. However, there is limited information regarding whether familial factors are associated with the risk of adolescent IDA.
Methods: This study evaluated the association between adolescent IDA and family history of IDA using data from the fifth Korea National Health Nutrition Survey (2010-2012). Data from 10-18-year-old children who underwent laboratory testing were analyzed.
Results: The overall prevalence of IDA was 3.1% (95% confidence interval [CI]: 2.4-4.1%), with prevalence of 0.5% among boys (95% CI: 0.2-1.3%) and 6.2% among girls (95% CI: 4.6-8.3%). The prevalence of IDA was associated with female sex (odds ratio [OR]: 13.43, 95% CI: 4.92-36.65; P<0.001) and a family history of IDA (OR: 3.12, 95% CI: 1.11-8.76; P=0.03). Other risk factors for IDA were receiving social welfare support (OR: 3.31, 95% CI: 1.45-7.56; P=0.031), low maternal education (OR: 3.12, 95% CI: 1.39-6.99; P=0.006), receiving charitable food support (OR: 2.27: 95% CI: 0.95-5.44; P=0.04), poor body-image (OR: 2.14, 95% CI: 1.16-3.93; P=0.026), and weight-loss efforts (OR: 2.42, 95% CI: 1.27-4.61; P=0.01). Nutritional supplementation protected against IDA (OR: 0.40, 95% CI: 0.19-0.82; P=0.007), although adolescents with awareness of nutritional labels had a high IDA prevalence (OR: 8.06, 95% CI: 1.71-38.05; P<0.001).
Conclusion: A family history of IDA was an independent risk factor for IDA. Further studies are needed to determine whether family-level educational interventions can reduce the risk of adolescent IDA.
Keywords: Anemia, Iron-deficiency, Adolescent, Family medical history
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October 2018, 25 (2)
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  • Jae Ho Yoo