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Original Article
Childhood Venous Thromboembolism in Yeungnam Region in Korea: Multicenter Study
Clin Pediatr Hematol Oncol 2018;25:43-9.
Published online April 30, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Soram Lee, M.D.1, Jong Hyuk Youn, M.D.1, Jae Young Lim, M.D.1, Hee Won Chueh, M.D.2, Jae Min Lee, M.D.3, Jin Kyung Suh, M.D.4, Ji Yoon Kim, M.D.4, Eu Jeen Yang, M.D.5, Kyung Mi Park, M.D.5, Young Tak Lim, M.D.5, Jikyoung Park, M.D.6, Eun Mi Choi, M.D.7, Ye Jee Shim, M.D.7, Heung Sik Kim, M.D.7, Sang Kyu Park, M.D.8, Seom Gim Kong, M.D.9, Eun Jin Choi, M.D.10 , Eun Sil Park, M.D.1,11

1Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, 2Department of Pediatrics, Dong-A University College of Medicine, Busan, 3Department of Pediatrics, Yeungnam University College of Medicine, Daegu, 4Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, 5Department of Pediatrics, Pusan National University Children’s Hospital, Yangsan, 6Department of Pediatrics, Inje University Busan Paik Hospital, Busan, 7Department of Pediatrics, Keimyung University School of Medicine, Daegu, 8Department of Pediatrics, Ulsan University College of Medicine, Ulsan, 9Department of Pediatrics, Kosin University College of Medicine, Busan, 10Department of Pediatrics, College of Medicine, Daegu Catholic University, Daegu, 11Health Science Institute, Gyeongsang National University College of Medicine, Jinju, Korea
Correspondence to: Eun Sil Park
Department of Pediatrics, Health Science Institute, Gyeongsang National University College of Medicine, Jinju-daero 816 beon-gil, Jinju 52727, Korea
Tel: +82-55-750-8829 Fax: +82-55-752-9339 E-mail: espark@gnu.ac.kr
Received March 26, 2018; Revised April 3, 2018; Accepted April 9, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Venous thromboembolism (VTE) is rare in pediatric patients compared to adults, but it’s incidence is gradually increasing. The purpose of this study was to analyze the incidence, risk factors, and prognosis of pediatric patients with VTE in Korea.
Methods: Between January 2000 and July 2017, 249,312 medical records of the patients older than 1 year who were hospitalized in the department of pediatrics of 10 university hospitals in Yeungnam region were retrospectively reviewed.
Results: The overall incidence of VTE was 4.9 per 10,000 admissions. Of the total 123 patients, 80 (65.0%) were male and the median age was 10.8 years (range, 1.0-23.5 years). Magnetic resonance imaging was performed most frequently to confirm the diagnosis of VTE (43.1%). Thrombosis occurred in the cerebral vessels (46.3%), lower extremities (23.8%), pulmonary (19.5%), abdomen (9.8%), and upper extremities (4.1%). One hundred and six patients had underlying causes such as cancer (27.6%), infection (26.8%), intravenous catheter insertion (17.9%), and surgery (14.6%). Protein C was evaluated in 39 patients (31.7%), protein S in 40 (32.5%), antithrombin (AT) III in 52 (42.3%), and homocysteine in 21 (17.1%). Among them, one patient with a family history of AT III deficiency had SERPINC gene mutation. Seventy-seven patients (62.6%) started anti-coagulation treatment. Most (52.0%) were treated for more than 90 days.
Conclusion: Healthcare providers must be aware of the potential for VTE development in childhood. In the near future, a nationwide survey should be investigated to determine the incidence rate and the trends in VTE among Korean children.
Keywords: Venous thromboembolism, Pediatric patients, Epidemiology
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April 2018, 25 (1)
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  • Eun Sil Park