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Case Report
A Case of Erdheim-Chester Disease Developed during Treatment of Leukemiain a Child
Clin Pediatr Hematol Oncol 2018;25:66-70.
Published online April 30, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Joon Pyo Hong, M.D., Won Ki Ahn, M.D., Joo Yeon Lim, M.D., Jo Eun Jung, M.D., Seung Min Hahn, M.D., Ph.D., Jung Woo Han, M.D., Ph.D., Chuhl Joo Lyu, M.D., Ph.D.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Chuhl Joo Lyu
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Tel: +82-2-2228-2060 Fax: +82-2-393-9118 E-mail: CJ@yuhs.ac
Received March 26, 2018; Revised April 4, 2018; Accepted April 15, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Erdheim-Chester disease (ECD) is a rare non-Langerhan’s cell histiocytosis disorder characterized by replacement of normal tissue by lipid-laden histiocytes affecting various organs. A few pediatric cases have been reported worldwide. Here we present a child with leukemia who was diagnosed as ECD. A 2-year and 11-month old boy diagnosed with high risk acute lymphoblastic leukemia (ALL) at the age of 17 months, received allogeneic hematopoietic stem cell transplantation (HSCT) at the age of 2 years old. Six months after the transplantation, the patient was admitted to the hospital with palpable left calf nodules. Bone marrow study suggested ECD without leukemia with complete chimerism status. Excisional biopsy of the left calf nodule showed ‘aggregation of non-Langerhan’s cell type epitheloid histiocytes’; clinically suggestive of ECD. The patient was started on vinblastine and corticosteroid treatment.
Keywords: Erdheim-Chester disease, Acute lymphoblastic leukemia, Child
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October 2018, 25 (2)
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  • Chuhl Joo Lyu