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Original Article
Predictive Value of Endometrial Thickness for Anemia in Adolescent Girls with Abnormal Uterine Bleeding
Clin Pediatr Hematol Oncol 2018;25:81-6.
Published online October 31, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Ji Sung Lee, M.D., Ph.D.1, Young Hwan Cho, M.D.2 and In-sang Jeon, M.D., Ph.D.2

Departments of 1Obstetrics and Gynecology and 2Pediatrics, College of Medicine, Gachon University, Incheon, Korea
Correspondence to: In-sang Jeon
Department of Pediatrics, College of Medicine, Gachon University, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, Korea
Tel: +82-32-460-8382
Fax: +82-32-460-3224
E-mail: isjeon@gilhospital.com
ORCID ID: orcid.org/0000-0001-8714-9403
Received September 16, 2018; Revised September 30, 2018; Accepted October 8, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Immaturity of the endocrine system that controls the normal menstrual cycle frequently results in abnormal uterine bleeding (AUB) and elicits anemia in adolescent girls. This study was conducted to assess the predictive value of endometrial thickness (ET) for anemia in adolescent girls with AUB.
Methods: A retrospective chart review was performed for a cohort of adolescents (12-18 years old) with AUB who presented over a 10-year period. Complete blood count and ultrasonographic data of 115 adolescent girls with AUB were analyzed. Subjects were classified according to ET as group I (ET <11 mm) and group II (≥11 mm), and the incidence of anemia was compared. Subjects were also classified according to age as group Y (12-15 years old of age) and group O (16-18 yr), and ET, hemoglobin (Hb), and incidence of anemia were compared.
Results: The incidence of anemia in all subjects was 67.8% and was significantly higher in group II than in group I (P<0.001). The incidence of severe anemia was 56.9% in group II, which was higher than in group I (P=0.039). The incidence of anemia was not significantly different between groups Y and O. However, the incidence of severe anemia was significantly higher in group Y than in group O (P=0.001).
Conclusion: AUB can result in severe anemia in adolescent girls particularly those who are close to menarche or have a thick endometrium. Early supervision of AUB is required in order to avoid anemia in adolescent girls with AUB.
Keywords: Adolescent girl, Abnormal uterine bleeding, Anemia


October 2018, 25 (2)
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  • In-sang Jeon