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Case Report
Cytomegalovirus-Associated Severe Direct Antiglobulin Test Negative Hemolytic Anemia: A Case Report
Clin Pediatr Hematol Oncol 2018;25:170-4.
Published online October 31, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Hyun Jung Hong, M.D.1, Young Hye Cho, M.D.1, Jae-Young Lim, M.D., Ph.D.1,2, Jung Sook Yeom, M.D., Ph.D.1,2, Ji Sook Park, M.D., Ph.D.1,2, Eun Sil Park, M.D., Ph.D.1,2, Ji-Hyun Seo, M.D., Ph.D.1,2, Hyang-Ok Woo, M.D., Ph.D.1,2 and Hee-Shang Youn, M.D., Ph.D.1,2

1Department of Pediatrics, College of Medicine, Gyeongsang National University, 2Gyeongsang Institute of Health Science, Jinju, Korea
Correspondence to: Jae-Young Lim
Department of Pediatrics, College of Medicine, Gyeongsang National University, 79 Gangnam-ro, Jinju 52727, Korea
Tel: +82-55-750-8161
Fax: +82-55-752-9339
Received July 17, 2018; Revised August 10, 2018; Accepted September 18, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cytomegalovirus is a common virus that is mostly asymptomatic when infected, but rarely causes life-threatening hemolysis especially in immunocompromised children. We report a case of antiglobulin test negative severe hemolytic anemia caused by cytomegalovirus infection developed in an immune competent 9-year-old girl. The patient’s hemoglobin level was 4.8 g/dL on the day of admission. The diagnosis was achieved by exclusion of other causes of hemolytic anemia and serological evidence of recent CMV infection. The patient was successfully treated with anti-viral agents and steroids resulting in recovery from anemia. Clinicians should consider cytomegalovirus infection in the differential diagnosis of hemolytic anemia in pediatric patients.
Keywords: Hemolytic anemia, Cytomegalovirus

October 2018, 25 (2)
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  • Jae-Young Lim 

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