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Case Report
A Case of Ethosuximide-Induced Aplastic Anemia Successfully Treated with Methylprednisolone Pulse Therapy
Clin Pediatr Hematol Oncol 2018;25:175-9.
Published online October 31, 2018
© 2018 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Hyun Sik Kang, M.D.1 and Sun Hyung Kim, M.D.2

Departments of 1Pediatrics and 2Laboratory Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea
Correspondence to: Hyun Sik Kang
Department of Pediatrics, Jeju National University School of Medicine, 15 Aran 13-gil, Jeju 63241, Korea
Tel: +82-64-717-1528
Fax: +82-64-717-1097
Received September 18, 2018; Revised October 1, 2018; Accepted October 9, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aplastic anemia may develop secondary to environmental exposure to entities such as chemicals, medical drugs, and infectious agents. Fatal complications from antiepileptic medications may occur despite careful and appropriate use. We report the case of a 9-year-old girl with a presenting diagnosis of aplastic anemia following treatment with ethosuximide for absence seizures. Aplastic anemia can now be cured with stem cell transplantation or immunosuppressive therapy. In this case, however, because of the impossibility of bone marrow transplantation and the specific needs of the patient’s parents, three courses of methylprednisolone pulse therapy were administered. Following the therapy, there was improvement in pancytopenia and complete remission in the bone marrow. No adverse side effects of therapy were observed. The authors suggest that methylprednisolone pulse therapy may be a treatment for acquired aplastic anemia.
Keywords: Aplastic anemia, Ethosuximide, Methylprednisolone, Anticonvulsants
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  • Hyun Sik Kang