search for


Case Report
Various Complications after a Vascular Procedure in Patients with Hemophilia
Clin Pediatr Hematol Oncol 2019;26:55-9.
Published online April 30, 2019
© 2019 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Yeon Soo Ha, and Young Shil Park

Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea
Correspondence to: Young Shil Park
Department of Pediatrics, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul 05278, Korea
Tel: +82-2-440-6133
Fax: +82-2-440-7175
Received March 20, 2019; Revised April 5, 2019; Accepted April 8, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Hemophilia, an inherited bleeding disorder, is caused by a deficiency of coagulation factor VIII or IX. Most of patients with hemophilia need vascular procedure, which can lead to complications. Even though these complications can also occur in normal people, hemophilia and coagulopathy are particular risk factors. We reviewed medical records of patients with hemophilia who underwent vascular procedures and investigated its complications. Vessel-related complications occurred in five patients. Three patients had pseudoaneurysms after radial arterial puncture. All patients underwent coagulation factor replacement or ultrasound-guided compression and showed improvement. Neuropathy developed in one patient due to a hematoma that occurred after blood sampling. The hematoma improved, but motor and sensory deficits remained and neuropathy was confirmed. One patient died of uncontrolled bleeding after angiography. Vascular procedures require more attention in patients with hemophilia. Caution and prevention of complications is essential, even before the patient is diagnosed with hemophilia.
Keywords: Bleeding, Complication, Hemophilia, Procedure, Vascular
  1. Kliegman RM, Stanton BF, St Geme JW, Schor N. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier, 2016;2384-7.
  2. Ellis G, John Camm A, Datta SN. Novel anticoagulants and antiplatelet agents; a guide for the urologist. BJU Int 2015;116:687-96.
    Pubmed CrossRef
  3. Esper RJ, Nordaby RA, Vilariño JO, Paragano A, Cacharrón JL, Machado RA. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol 2006;5:4.
    Pubmed KoreaMed CrossRef
  4. Sueyoshi E, Sakamoto I, Nakashima K, Minami K, Hayashi K. Visceral and peripheral arterial pseudoaneurysms. AJR Am J Roentgenol 2005;185:741-9.
    Pubmed CrossRef
  5. Afshar A, Nasiri B. Radial artery pseudoaneurysm at the previous site of invasive monitoring. J Teh Univ Heart Ctr 2009;3:193-6.
  6. Fields JM, Saluja S, Schwartz DS, Touloukian RJ, Keller MS. Hemophilia presenting in an infant as a radial artery pseudoaneurysm following arterial puncture. Pediatr Radiol 1997;27:763-4.
    Pubmed CrossRef
  7. Kim BB, Ju HY, Park YS, Bae CW. Arterial pseudoaneurysm in neonates with hemophilia: successful treatment with noninvasive clotting factor replacement and ultrasound-guided compression. Neonatal Med 2014;21:198-203.
  8. Kent KC, Moscucci M, Gallagher SG, DiMattia ST, Skillman JJ. Neuropathy after cardiac catheterization: incidence, clinical patterns, and long-term outcome. J Vasc Surg 1994;19:100813.
    Pubmed CrossRef
  9. Chung TS, Sim WJ, Cha SJ, Park SJ, Lim HM. A case of femoral neuropathy after renal transplantation. J Korean Soc Transplant 2002;16:133-6.
  10. Kong WK, Cho KT, Lee HJ, Choi JS. Femoral neuropathy due to iliacus muscle hematoma in a patient on warfarin therapy. J Korean Neurosurg Soc 2012;51:51-3.
    Pubmed KoreaMed CrossRef
  11. Tuinenburg A, Damen SA, Ypma PF, Mauser-Bunschoten EP, Voskuil M, Schutgens RE. Cardiac catheterization and intervention in haemophilia patients: prospective evaluation of the 2009 institutional guideline. Haemophilia 2013;19:370-7.
    Pubmed CrossRef
  12. Boehnel C, Rickli H, Graf L, Maeder MT. Coronary angiography with or without percutaneous coronary intervention in patients with hemophilia-Systematic review. Catheter Cardiovasc Interv 2018;92:1-15.
    Pubmed CrossRef

October 2019, 26 (2)
Full Text PDF
Send to a friend

Cited By Articles
  • CrossRef (0)

Author ORCID Information
  • Young Shil Park