search for


Case Report
Primary Cardiac Hemangioendothelioma in an Infant: A Case Report
Clin Pediatr Hematol Oncol 2019;26:60-5.
Published online April 30, 2019
© 2019 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Jeong-wook Seo1, Mi Kyoung Song2, Sung-hye Park3, Hye Eun Park3, and Sin Ae Park1

1Presbyterian Medical Center, Jeonju, 2Department of Pediatrics, Seoul National University Children’s Hospital, 3Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
Correspondence to: Sin Ae Park
Presbyterian Medical Center, 365 Seowon-ro, Wansan-gu, Jeonju 54987, Korea
Tel: +82-63-230-1390
Fax: +82-63-230-1396
Received March 24, 2019; Revised April 4, 2019; Accepted April 16, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary cardiac tumors are rare, with a prevalence of 0.001-0.2%. Among such tumors, cardiac hemangioendotheliomas are some of the most uncommon. In Korea, there have been no reports of hemangioendothelioma occurring in the heart of infants. We herein report a case of an infant that was admitted to our medical center and presented with cough and a runny nose. The initial diagnosis was acute bronchiolitis. Cardiomegaly was observed on chest radiography. Echocardiography revealed a tumor measuring 3.5×4.0 cm in the right atrium. The infant was transferred to a tertiary medical center for tumor excision. The excised lesion was 3.8×3×3.2 cm in size, and biopsy confirmed a diagnosis of hemangioendothelioma. In this case report, we describe our experience with a rare case involving cardiac tumor in an infant with an upper respiratory tract infection.
Keywords: Hemangioendothelioma, Heart, Infant, Twins
  1. Petrella F, Bonalumi G, Andreini D, De Camilli E, Spaggiari L, Alamanni F. Primary epithelioid hemangioendothelioma of the heart. Am Surg 2018;84:e199-200.
  2. Beaton A, Kuttler T, Hassan A, et al. Hemangioendothelioma:a rare case of a primary intracardiac tumor. Pediatr Cardiol 2013;34:194-7.
    Pubmed CrossRef
  3. Arafa S, Sanad M. Primary cardiac hemangioendothelioma of the mitral valve. Egypt Heart J 2018;70:229-32.
    Pubmed KoreaMed CrossRef
  4. Requena L, Kutzner H. Hemangioendothelioma. Semin Diagn Pathol 2013;30:29-44.
    Pubmed CrossRef
  5. Erkan AN, Bal N, Kiroglu E. A case report of hemangioendothelioma of the hard palate. B-ENT 2008;4:175-8.
  6. Kutzner H, Mentzel T. Hemangioendotheliomas: heterogeneous vascular neoplasms. Dermatopathol Pract Concept 1999;5:102-9.
  7. Vanhoenacker FM, Parizel PM, Gielen JL. Imaging of soft tissue tumors. New York: Springer, 2017;187-96.
  8. Sugimoto T, Yamamoto K, Yoshii S. A primary epithelioid hemangioendothelioma of the right atrium: report of a case and literature review. Open J Thorac Surg 2013;3:63-7.
  9. Gasparovic H, Anic D, Saric D, Gasparovic V, Djuric Z, Jelic I. Surgical excision of a hemangioendothelioma of the left ventricle. Ann Thorac Surg 2002;74:914-6.
    Pubmed CrossRef
  10. Allain G, Hajj-Chahine J, Lacroix C, Tomasi J, Corbi P, Jayle C. Surgical management of an epithelioid hemangioendothelioma of the superior vena cava protruding into the right atrium. J Card Surg 2014;29:779-81.
    Pubmed CrossRef
  11. Chang JS, Young ML, Chuu WM, Lue HC. Infantile cardiac hemangioendothelioma. Pediatr Cardiol 1992;13:52-5.
    Pubmed CrossRef

October 2019, 26 (2)
Full Text PDF
Send to a friend

Cited By Articles
  • CrossRef (0)

Author ORCID Information
  • Sin Ae Park