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Review Article
Neonatal Thrombocytopenia: Diagnostic Approach and Platelet Transfusion Guideline
Clin Pediatr Hematol Oncol 2019;26:67-76.
Published online October 31, 2019
© 2019 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Ji Sook Kim and Ji Yoon Kim

Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea
Correspondence to: Ji Yoon Kim
Department of Pediatrics, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
Tel: +82-53-200-5704
Fax: +82-53-425-6683
E-mail: phojyk@knu.ac.kr
ORCID ID: orcid.org/0000-0002-5577-6629
Received August 16, 2019; Revised September 10, 2019; Accepted September 24, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Neonatal thrombocytopenia, defined as platelet counts of less than 150,000/µL, is a frequent hematologic abnormality in neonatal period. Differential diagnosis of neonatal thrombocytopenia may be challenging to pediatric hematologists and neonatologists because neonatal thrombocytopenia is associated with diverse maternal or neonatal clinical conditions. An accurate diagnosis for neonatal thrombocytopenia will lead to appropriate evaluation and management. Platelet transfusion is the primary management of neonatal thrombocytopenia. Most thrombocytopenic newborns received platelet concentrates to prevent major hemorrhage or treat ongoing bleeding according to institutional policy. However, scientific evidences for benefit and consistent guideline for platelet transfusion in neonates are lacking, further investigation to establish the standard recommendation for platelet transfusion is needed. This article reviewed the diagnostic approach and current guideline for platelet transfusion management for neonatal thrombocytopenia.
Keywords: Neonate, Infant, Thrombocytopenia, Platelets, Transfusion
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October 2019, 26 (2)
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  • Ji Yoon Kim