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Case Report
Embryonal Carcinoma of the Pineal Gland Developed in an Adolescent Boy with Klinefelter Syndrome
Clin Pediatr Hematol Oncol 2019;26:105-9.
Published online October 31, 2019
© 2019 Korean Society of Pediatric Hematology-Oncology

Hyo Jin Choi1, Eun Ah Kim1, Jae Min Lee1, Kyung Mi Jang1 and Joon Hyuk Choi2

Departments of 1Pediatrics and 2Pathology, Yeungnam University Hospital, Daegu, Korea
Correspondence to: Kyung Mi Jang
Department of Pediatrics, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
Tel: +82-53-620-3532
Fax: +82-53-629-2252
Jae Min Lee
Department of Pediatrics, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
Tel: +82-53-620-3536
Fax: +82-53-629-2252
Received July 16, 2019; Revised September 12, 2019; Accepted October 5, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Klinefelter syndrome (KS) is characterized by small testes, gynecomastia, tall stature, and hypergonadotropic hypogonadism. This condition is associated with extra X chromosomes. It is well known that these aneuploidies predispose individuals to the development of several cancers. Moreover, there are many case reports that show KS patients to have a higher relative risk for the development of malignancy. However, incracranial germ cell tumor (ICGCT) associated with KS is very uncommon. Herein, we report delayed diagnosis of KS in a 15-year-old boy with ICGCT, embryonal carcinoma of the pineal gland, after multimodality treatment in Korea.
Keywords: Klinefelter syndrome, Aneuploidy, Intracranial germ cell tumor
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October 2019, 26 (2)
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  • Jae Min Lee 
  • Kyung Mi Jang