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Case Report
Two Cases of Cytomegalovirus Infection Developed in Pediatric Acute Lymphoblastic Leukemia Patients
Clin Pediatr Hematol Oncol 2019;26:115-8.
Published online October 31, 2019
© 2019 Korean Society of Pediatric Hematology-Oncology and Korean Society for Pediatric Neuro-Oncology

Nayoung Jung1, Donghyun Kim1, Hee Seung Chin2 and Soon Ki Kim1

Departments of 1Pediatrics and 2Ophthalmology, Inha University Hospital, Incheon, Korea
Correspondence to: Soon Ki Kim
Department of Pediatrics, Inha University Hospital, 27 Inhang-ro, Jung-gu, Incheon 22332, Korea
Tel: +82-32-890-2843
Fax: +82-32-890-2844
E-mail: pedkim@inha.ac.kr
ORCID ID: orcid.org/0000-0002-4785-1705
Received September 17, 2019; Revised October 5, 2019; Accepted October 19, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
A 14 year-old boy with acute lymphoblastic leukemia (ALL) on maintenance chemotherapy presented with vision-threatening cytomegalovirus (CMV) retinitis. Treatment with intavitreal ganciclovir injection (2 mg/0.1 mL) followed by oral ganciclovir resulted in successful resolution of CMV retinitis. Another 13 year-old boy with ALL on maintenance chemotherapy presented with prolonged fever with no response to antibiotics administration. CMV and real-time PCR revealed positive result and a titer of 2,618,700 copies/mL, respectively. Ganciclovir was used for more than the approved duration of treatment, but viral titer frequently recurred with elevated liver enzymes and fever. In these 2 cases of CMV infection, a high index of suspicion and prompt management is important in children receiving ALL chemotherapy.
Keywords: Cytomegalovirus, Acute lymphoblastic leukemia
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October 2019, 26 (2)
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  • Soon Ki Kim