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  • Current Knowledge on Inherited Platelet Function Disorders

    Normal platelet function in primary hemostasis at the damaged vessel wall and the associated inherited platelet function disorders. vWF, von Willebrand factor; GP, glycopretein; TXA2, thromboxane A2; ADP, adenosine diphosphate; PS, phosphatidylserine.

  • Immunotherapy in Pediatric Hematologic Malignant Neoplasms

    Schema of immunotherapeutic modalities for hematologic malignancy. Antibody-based and cell-based immunotherapies including blinatumomab, inotuzumab, and chimeric antigen receptor (CAR) T cell, have been clinically translated (Adopted from Schultz L et al. Hematology Am Soc Hematol Educ Program. 2019;2019:226-32.).

  • Immunotherapy in Pediatric Solid Tumors

    Schematic diagrams of the mechanisms of action of CTLA-4, PD-1 and PD-L1 blockade with or without chimeric antigen receptor T cell (CAR-T) therapy [36,58]. (A) T-cell activation, attenuation by normal inhibitory signals, and negative regulation using anti-CTLA-4, anti-PD-1 or anti-PD-L1 antibody therapy. (B) CAR-mediated activation, attenuation by tumor and checkpoint mediated inhibitory signals. Checkpoint receptor binding and checkpoint ligand blocking antibodies may synergize with chimeric antigen receptor therapy. APC, antigen presenting cell; CTLA-4, cytotoxic T-lymphocyte-associated antigen-4; PD-1, programmed cell death receptor; PD-L1, programmed death-ligand 1; TAA, tumor-associated antigen; TCR, T-cell receptor.

Clin Pediatr Hematol Oncol 2020;27:1-71
Review Articles
Current Knowledge on Inherited Platelet Function Disorders
Nani Jung and Ye Jee Shim
Clin Pediatr Hematol Oncol 2020;27:1-13.
Immunotherapy in Pediatric Hematologic Malignant Neoplasms
Kyung Taek Hong
Clin Pediatr Hematol Oncol 2020;27:14-21.
Immunotherapy in Pediatric Solid Tumors
Jung Yoon Choi
Clin Pediatr Hematol Oncol 2020;27:22-31.
A Recent Update on Histiocytic Disorder in Children: Focus on Diagnosis and Treatment
Hoi Soo Yoon
Clin Pediatr Hematol Oncol 2020;27:32-42.
Management of Hepatoblastoma in the Modern Era and Future Perspectives
Jin Kyung Suh, Sunghan Kang, Hyery Kim, Kyung-Nam Koh and Ho Joon Im
Clin Pediatr Hematol Oncol 2020;27:43-54.
Pediatric Palliative Care
Min Sun Kim
Clin Pediatr Hematol Oncol 2020;27:55-60.
Original Article
Primary Extragonadal Germ Cell Tumors in Klinefelter Syndrome: 10-Years of Experience from a Single Institute
Yura Kim, Won Kee Ahn, Jung Woo Han, Seung Min Hahn, Seung Yeon Kwon and Chuhl Joo Lyu
Clin Pediatr Hematol Oncol 2020;27:61-6.
Case Report
A Case of Von Hippel-Lindau Disease Presented with Multiple Pancreatic Cysts and Medullary Hemangioblastoma
Young Hyun Kim, Hye Lim Jung, Aram Yang, Ji Hee Kwak, Deok Soo Kim, Jung Yeon Shim and Jae Won Shim
Clin Pediatr Hematol Oncol 2020;27:67-71.

April 2020, 27 (1) :1-71
Clin Pediatr Hematol Oncol


ISSN 2233-5250 (Print edition)
ISSN 2233-4580 (Online edition)
Phone: +82-2-516-6581
Fax: +82-2-516-6582
E-mail: journal@cpho.or.kr

  • Aims and Scope
Clinical Pediatric Hematology-Oncology (Clin Pediatr Hematol Oncol, CPHO) is a peer-reviewed open-access journal and the official journal of the Korean Society of Pediatric Hematology-Oncology (KSPHO). CPHO aims to deliver new and important scientific knowledge and information regarding clinical and biological aspects of the pediatric hematology and oncology to contribute to healthcare of children, adolescents and young adults. more
Basic Understanding of Iron Metabolism
Jin Kyung Suh, M.D., Ph.D., In-sang Jeon, M.D.
Received March 26, 2018; Accepted April 9, 2018.
Iron Contents in Rice Food Derived from the Iron Pot, and In Vitro Study Regarding Heme Oxygenase-1 Activity
Keun Young Kim, M.D., Young Min An, M.D., Tae Wan Kim, M.D., Yong Hun Jun, M.D., Ph.D., Ji Eun Lee, M.D., Ph.D., Jun Hyuk Jang, Ph.D. and Soon Ki Kim, M.D., Ph.D.
Received September 20, 2016; Accepted October 15, 2016.
Hemophagocytic Lymphohistiocytosis
Sun Young Park, M.D. and Jae Min Lee, M.D.
Received March 26, 2017; Accepted April 21, 2017.
Clinical Course of Childhood Immune Thrombocytopenic Purpura and Analysis Predicting Factor of Prognosis
Taekwan Lee, M.D., Jinhyuk Choi, M.D. and Yeon-Jung Lim, M.D., Ph.D.
Received September 25, 2017; Accepted October 12, 2017.