Summary of reported cases of pediatric leukemia presenting with osteolytic lesion and hypercalcemia: literature review
Authors | Case number |
Age/sex | Leukemia phenotype |
Osteolytic bone involvement |
---|---|---|---|---|
Hibi et al. [4] | Case 1 | 8 year/M | BCP-ALL | Hypercalcemia and multiple osteolytic lesion and fractures |
Case 2 | 3 year/F | BCP-ALL | Hypercalcemia and multiple osteolytic lesion | |
Chen et al. [9] | Case 3 | 13 year/M | BCP-ALL | Hypercalcemia and osteolytic lesion in skull and extremities |
Shahnazi et al. [10] | Case 4 | 4 year/F | ALL | Dorso-lumbar vertebra |
Case 5 | 4 year/F | ALL | Metacarpal bones, radius & ulna metaphysis | |
Case 6 | 8 year/M | ALL | Right humerus | |
Case 7 | 6 year/F | AML | Distal femur, proximal tibia, left femur neck | |
Case 8 | 5 year/M | AML | Right humeral metaphysis | |
Case 9 | 8 year/M | ALL | Thoraco-lumbar vertebra | |
Case 10 | 6 year/F | ALL | Bilateral distal femur, proximal tibia Right distal radius, ulna |
|
Case 11 | 9 year/M | ALL | Left femur epiphysis and proximal metaphysis | |
Case 12 | 13 year/F | ALL | Skull bone, iliac bones, lumbar vertebra, bilateral scapular bone | |
Case 13 | 2 year/F | ALL | Left humerus | |
Sirelkhatim et al. [11] | Case 14 | 17 year/M | ALL | Lumbosacral area, pelvic bones |
Case 15 | 12 year/F | ALL | Thoracic vertebra and femur | |
Case 16 | 7 year/M | ALL | Lumbosacral vertebra | |
Buonuomo et al. [12] | Case 17 | 9 year/F | BCP-ALL | Right proximal femur, bilateral tibia and ulna, right distal humerus |
Shanks et al. [13] | Case 18 | 14 year/F | BCP-ALL | Hypercalcemia and rib osteolytic lesion |
Ganesan et al. [14] | Case 19 | 16 year/M | ALL | Hypercalcemia and osteolytic lesion of skull, ribs, vertebral bodies, pelvis and long bones of extremities |
Trehan et al. [15] | Case 20 | 9 year/M | B-ALL | Hypercalcemia |
Case 21 | 8 year/M | Philadelphia positive ALL | Hypercalcemia and osteolytic lesion of thoraco-lumbar vertebra |