Table. 1.

Table. 1.

Summary of reported cases of pediatric leukemia presenting with osteolytic lesion and hypercalcemia: literature review

Authors Case
number
Age/sex Leukemia
phenotype
Osteolytic bone involvement
Hibi et al. [4] Case 1 8 year/M BCP-ALL Hypercalcemia and multiple osteolytic lesion and fractures
Case 2 3 year/F BCP-ALL Hypercalcemia and multiple osteolytic lesion
Chen et al. [9] Case 3 13 year/M BCP-ALL Hypercalcemia and osteolytic lesion in skull and extremities
Shahnazi et al. [10] Case 4 4 year/F ALL Dorso-lumbar vertebra
Case 5 4 year/F ALL Metacarpal bones, radius & ulna metaphysis
Case 6 8 year/M ALL Right humerus
Case 7 6 year/F AML Distal femur, proximal tibia, left femur neck
Case 8 5 year/M AML Right humeral metaphysis
Case 9 8 year/M ALL Thoraco-lumbar vertebra
Case 10 6 year/F ALL Bilateral distal femur, proximal tibia
Right distal radius, ulna
Case 11 9 year/M ALL Left femur epiphysis and proximal metaphysis
Case 12 13 year/F ALL Skull bone, iliac bones, lumbar vertebra, bilateral scapular bone
Case 13 2 year/F ALL Left humerus
Sirelkhatim et al. [11] Case 14 17 year/M ALL Lumbosacral area, pelvic bones
Case 15 12 year/F ALL Thoracic vertebra and femur
Case 16 7 year/M ALL Lumbosacral vertebra
Buonuomo et al. [12] Case 17 9 year/F BCP-ALL Right proximal femur, bilateral tibia and ulna, right distal humerus
Shanks et al. [13] Case 18 14 year/F BCP-ALL Hypercalcemia and rib osteolytic lesion
Ganesan et al. [14] Case 19 16 year/M ALL Hypercalcemia and osteolytic lesion of skull, ribs, vertebral bodies, pelvis and long bones of extremities
Trehan et al. [15] Case 20 9 year/M B-ALL Hypercalcemia
Case 21 8 year/M Philadelphia positive ALL Hypercalcemia and osteolytic lesion of thoraco-lumbar vertebra
Clin Pediatr Hematol Oncol 2024;31:36-40
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