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  • Haploidentical Family Donor Transplantation for Pediatric Hematologic Malignancies

    Haploidentical family donor hematopoietic stem cell transplantation (Haplo-HSCT) has been increasingly used for patients who require transplant for optimum therapy, but lack a human leukocyte antigen (HLA)-matched donor. Important variables that require consideration in choosing one of potentially many haplo-donors include evaluation for presence of donor-specific anti-HLA antibodies, the age and gender of the donor, the parental relationship of the donor especially for pediatric patients, and ABO compatibility. Three major platforms have been reported as valid methods of undertaking haplo-HSCT. Ex vivo T cell depleted transplant may allow for low rates of graft-versus-host disease, even without pharmacological prophylaxis after transplant. Major impediments such as delayed immune recovery and subsequent infections may be overcome by depletion of specific T cell subsets, as done in αβ T cell/B cell depleted transplants. Alternatively, T cell replete haplo-HSCT may be undertaken with post-transplantation cyclophosphamide, or by administering intensive pre- and post-transplant immunosuppression including use of anti-thymocyte globulin. All three haplo-HSCT platforms have been successfully used to treat children with hematologic malignancies. As this method of HSCT is relatively new, long-term follow-up is necessary to improve outcomes and clarify the toxicities of this transplant modality.

  • Comparison of the Efficacy of Piperacillin/Tazobactam and Meropenem, with or without Intravenous Immunoglobulin, as Second-Line Therapy for Febrile Neutropenia: A Prospective, Randomized Study

    Flow chart of the febrile neutropenic episodes enrolled in the present study. PIPC/TAZ, pi-peracillin/tazobactam; MEPM, mero-penem; IVIG, intravenous immuno-globulin.

  • A Pediatric Case of Atypical Chronic Myeloid Leukemia with CSF3R Mutation Not Responding to Ruxolitinib, but Rescued by Allogeneic Transplantation

    (A) The computed tomo-graphy of the patient’s brain at admission shows a 6.5 cm acute intracranial hemorrhage in the left frontal lobe with perilesional edema and midline shifting to the right. (B) An initial peripheral blood smear reveals left-shifted myeloid hyper-plasia with dysplasia (myeloblasts 2%, myelocytes 20% and metamy-elocytes 3% of the leukocytes) (Weight-Giemsa stain, ×400). (C) A bone marrow smear reveals in-creased granulocytic series with 8.7% myeloblasts and dysgranulo-poiesis (Weight-Giemsa stain, ×400). (D) A follow-up bone marrow smear of the patient 3 months after the initial evaluation shows increased myeloblasts of 14% (Weight-Giemsa stain, ×400). (E) Magnetic reson-ance imaging of brain 11 months later shows en-cephalomalacic change with hemo-siderin deposit in left frontal lobe and corpus callosum, sequelae of previous intracranial hemorrhage.

Clin Pediatr Hematol Oncol 2021;28:67-102
Review Article
Haploidentical Family Donor Transplantation for Pediatric Hematologic Malignancies
Jae Wook Lee
Clin Pediatr Hematol Oncol 2021;28:67-74.
Original Article
Comparison of the Efficacy of Piperacillin/Tazobactam and Meropenem, with or without Intravenous Immunoglobulin, as Second-Line Therapy for Febrile Neutropenia: A Prospective, Randomized Study
Hirozumi Sano, Ryoji Kobayashi, Satoru Matsushima, Daiki Hori, Masato Yanagi, Koya Kodama, Daisuke Suzuki, and Kunihiko Kobayashi
Clin Pediatr Hematol Oncol 2021;28:75-83.
Case Reports
A Boy with X-Linked Inhibitor of Apoptosis Protein (XIAP) Deficiency as the Initial Presentation of Pure Red Cell Aplasia
Soo Yeun Sim, Hye Yeon Choi, Seung Bum Han, Nack Gyun Chung, Bin Cho, MyungShin Kim, and Dae Chul Jeong
Clin Pediatr Hematol Oncol 2021;28:84-8.
RUNX1 Germline Mutation in a Patient with Chronic Thrombocytopenia
Yujin Nam, Gyu Min Yeon, and Seom Gim Kong
Clin Pediatr Hematol Oncol 2021;28:89-92.
A Pediatric Case of Atypical Chronic Myeloid Leukemia with CSF3R Mutation Not Responding to Ruxolitinib, but Rescued by Allogeneic Transplantation
Yoon Jung Choi, Hee Jo Baek, Bo Ram Kim, Soo Min Park, Myung-Geun Shin, and Hoon Kook
Clin Pediatr Hematol Oncol 2021;28:93-7.
A Case of Adrenal Myelolipoma Associated with Hereditary Spherocytosis
Dahui Gug, Ha Young Park, Bo Lyun Lee, Kwang Hoon Kim, Jeong Eun Lee, and Ji Kyoung Park
Clin Pediatr Hematol Oncol 2021;28:98-102.

October 2021, 28 (2) :67-102
Clin Pediatr Hematol Oncol


ISSN 2233-5250 (Print edition)
ISSN 2233-4580 (Online edition)
Phone: +82-2-516-6581
Fax: +82-2-516-6582
E-mail: journal@cpho.or.kr

  • Aims and Scope
Clinical Pediatric Hematology-Oncology (Clin Pediatr Hematol Oncol, CPHO) is a peer-reviewed open-access journal and the official journal of the Korean Society of Pediatric Hematology-Oncology (KSPHO). CPHO aims to deliver new and important scientific knowledge and information regarding clinical and biological aspects of the pediatric hematology and oncology to contribute to healthcare of children, adolescents and young adults. more
Basic Understanding of Iron Metabolism
Jin Kyung Suh, M.D., Ph.D., In-sang Jeon, M.D.
Received March 26, 2018; Accepted April 9, 2018.
Vascular Anomaly: An Updated Review
Meerim Park
Received March 24, 2019; Accepted April 6, 2019.
A Recent Update on Histiocytic Disorder in Children: Focus on Diagnosis and Treatment
Hoi Soo Yoon
Received April 6, 2020; Accepted April 21, 2020.
Hemophagocytic Lymphohistiocytosis
Sun Young Park, M.D. and Jae Min Lee, M.D.
Received March 26, 2017; Accepted April 21, 2017.